Functional Lab TestinG

At The Facility, we run several types of specialty lab testing to isolate the root cause of many chronic symptoms and conditions. The companies that perform these tests are nationwide; many test kits can be drop-shipped directly to your home. We do our best to offset the cost of Functional Medicine care by using your health insurance for lab fees as much as possible. Below are some of the common lab tests we use, although more specific advanced testing is available.

Comprehensive

BIOSCREEN

Functional blood chemistry is focused on investigating and determining the underlying and contributing causes of health imbalances and health conditions. It provides a comprehensive overview of the different systems of the body to determine what metabolic and biochemical imbalances exist that could determine the potential for health as well as for illness. As such, the analysis is based on “functional ranges” to assess the imbalances. This allows us to develop a more targeted diet and lifestyle program to optimize health potential.

 

For many this may provide a sense of relief if they have been told that there is nothing wrong with them, even while they are experiencing symptoms. We start our health evaluation with a Comprehensive Bio-Screen which includes five pages worth of lab markers – liver, kidney, lipids, blood sugar, electrolytes, minerals, immune function, iron studies, red blood cell function, inflammatory markers, comprehensive thyroid panel, and much more.

The Comprehensive Bio-Screen is a combination blood and urine test, analyzing 80 total biomarkers. This test encompasses multiple organ systems analysis, to help us evaluate your baseline health status.

 

The following is a list of the key areas we analyze in your biochemistry with the bio-screen.

  • Blood sugar analysis

  • Cardiovascular analysis

  • Infection analysis

  • Electrolyte analysis

  • Anemia analysis

  • Comprehensive thyroid analysis*

  • Lipid analysis

  • Liver & biliary analysis

  • Urinalysis

  • Vitamin D Status

  • Inflammatory analysis 

 

 

*10 total thyroid biomarkers, including two different antibodies. The thyroid section in this panel is carefully selected to reveal certain essential mechanisms that may be important for proper thyroid hormone synthesis and function. This unique panel gives us an unprecedented perspective to the various biosystems with expanded markers pertaining specifically to thyroid physiology.

 
 

GI effects

comprehensive profile - stool

This is a 3-day stool collection; an advanced stool test that provides us with immediate, actionable clinical intelligence for the management of gastrointestinal health. This test utilizes cutting-edge technologies and biomarkers.

 

This test offers valuable insight into:

  • Digestive function (Digestion, absorption, and enzyme markers)

  • Intestinal inflammation or immune activation

  • Intestinal microbiome

 

**We utilize the GI Effects panel when we suspect a GI infection or gut dysbiosis.**

 

Genova Diagnostics utilizes polymerase chain reaction (PCR) technology (genetic sequencing) to analyze each sample for parasitic DNA as well as uses PCR to analyze each patient’s unique microbiome. With PCR technology, we are able to get a real-time quantification of all of the organisms in your stool.

 

GI Effects is a comprehensive assessment of complete GI health; able to assess the root cause of most gut complaints, such as gas, bloating, indigestion, abdominal pain, diarrhea, and constipation. These biomarkers provide valuable insight into the development of strategic interventions, aimed at correcting functional imbalances and inadequacies through targeted dietary, lifestyle, and pharmaceutical-grade supplementation therapies.

 

The GI Effects also uses biomarkers which help us differentiate between conditions such as Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).

 

Nutreval -comprehensive nutritional analysis - blood/urine

The NutrEval is an advanced nutritional analysis designed to reveal nutritional imbalances or inadequacies. The test evaluates functional need for:

  • Antioxidants

  • B-vitamins

  • Minerals

  • Essential fatty acids

  • Digestive support

  • Other select nutrients

 

This analysis allows us insight into nutrient status and helps us provide targeted treatment for YOUR needs. With targeted information, this often augments a speedy recovery.

 

When might we consider a NutrEval?

  • Mood disorders (depression, anxiety)

  • Fatigue

  • GI complaints

  • Chronic Pain/Inflammatory conditions

  • Migraine

  • Cardiovascular risk

  • Weight issues/dietary guidance

  • General health

  • Sports fitness optimization

 

 

The NutrEval offers:

  • Metabolic analysis (urine organic acids)

    • Malabsorption and dysbiosis markers

      • Malabsorption markers

      • Bacterial dysbiosis markers

      • Yeast/fungal dysbiosis markers

    • Cellular energy and mitochondrial metabolites

      • Carbohydrate metabolism

      • Energy metabolism

      • Fatty acid metabolism

    • Neurotransmitter metabolites

    • Vitamin markers

    • Toxin & detoxification markers

    • Tyrosine metabolism

  • Plasma amino acid analysis (essential AND non-essential amino acids, PLUS metabolites)

  • Essential and metabolic fatty acids (red blood cell essential and non-essential fatty acids)

    • Omega 3’s

    • Omega 6’s

    • Omega 9’s

    • Saturated fatty acids

    • Monounsaturated fats

      • Omega 7’s

      • Trans fat

    • Delta-6 Desaturase Activity

    • Cardiovascular risk – featuring key ratios: omega 6:omega 3, AA/EPA, and the Omega-3 Index

  • Oxidative stress analysis (blood and urine biomarkers indicative of oxidative stress)

    • Glutathione (whole blood)

    • Lipid Peroxides (urine)

    • 8-OHdG (urine)

    • Coenzyme Q10 (serum)

  • Elemental markers

    • Nutrient Elements

      • Copper

      • Magnesium

      • Manganese

      • Potassium

      • Selenium

      • Zinc

    • Toxic Elements

      • Lead

      • Mercury

      • Antimony

      • Arsenic

      • Cadmium

      • Tin

  • Certain genetic polymorphisms, such as those involved in methylation, inflammation, cancer risk, heart disease/dementia risk, and dopamine metabolism.

ENVIROtox complete profile 

ENVIROtox Complete Profile – (Urine) - Great Plains Laboratory

The ENVIROtox Complete Profile includes the following tests:

  • GPL-TOX: Toxic Organic Chemical Profile

  • Organic Acids Test

  • Glyphosate Test

  • MycoTOX Profile

 

Every day, we are exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides, packaged foods, household products, and environmental pollution. As we have become more exposed to chemical-laden products and to toxic chemicals in food, air, and water, we have been confronted with an accelerating rate of chronic illnesses like:

  • Cancer

  • Heart disease

  • Chronic fatigue syndrome

  • Chemical sensitivity

  • Autism spectrum disorders

  • ADD/ADHD

  • Autoimmune disorders

  • Parkinson’s Disease

  • Alzheimer’s disease

 

The ENVIROtox Panel will give us a comprehensive look at your current toxic chemical burden, as well as any resulting oxidative stress, inflammation, and mitochondrial damage.

 

GPL-TOX

Exposure to environmental pollutants has been linked to many chronic diseases. It analyzes your urine and screens for the presence of 172 different toxic chemicals using 18 unique metabolites, including:

  • Organophosphate pesticides

  • Phthalates

  • Benzene

  • Xylene

  • Vinyl chloride

  • Pyrethroid insecticides

  • Acrylamide

  • Perchlorate

  • Diphenyl phosphate

  • Ethylene oxide

  • Acrylonitrile

  • Many others

 

Also- this profile includes a marker known to be associated with mitochondrial dysfunction resulting from mutations of mitochondrial DNA. These mutations can be caused by exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

 

GPL-TOX uses advanced mass spectrometry analysis. This is necessary to detect lower levels of certain chemicals and toxic markers which convention mass spectrometry often misses.

 

Organic Acids Test (OAT)

The OAT has 76 markers and gives us a metabolic snapshot of your health. This panel includes specific markers for oxidative stress and inflammation, including multiple markers often elevated in either acute or chronic toxic chemical exposure and/or when the body is not properly detoxifying chemicals.

 

This test also yields accurate evaluation of intestinal yeast and bacteria, important neurotransmitter information, nutritional markers, glutathione status, oxalate metabolism, and much more.

 

Glyphosate Test

Glyphosate is the world’s most widely used herbicide and is the primary ingredient in RoundUp ™ . in addition, it is a broad-spectrum herbicide that is used in more than 700 different products from agriculture and forestry to home use. The World Health Organization International Agency for Research on Cancer published a summary in March 2015 that classified glyphosate as a probable carcinogen in humans.

 

MycoTOX Profile

Mycotoxins are metabolites produced by fungi like mold, which can infest buildings, vehicles, and foodstuffs. They are some of the most prevalent toxins in the environment. Diseases and symptoms linked to mycotoxin exposure include:

  • Fever

  • Pneumonia-like symptoms

  • Heart disease

  • Rheumatic disease

  • Asthmas

  • Sinusitis

  • Cancer

  • Memory loss

  • Vision loss

  • Chronic fatigue

  • Skin rashes

  • Depression

  • ADHD

  • Anxiety

  • Liver damage

 

The MycoTOX Profile screens for 11 different mycotoxins, from 40 species of mold, in one urine sample. It uses advanced mass spectrometry. This is necessary to detect lower levels of these fungal toxins.

DUTch plus comprehensive hormone assessment

We use urinary hormone assessments as a much more “real-time” analysis of hormone function in men and women using dried urine testing for comprehensive hormones (DUTCH).  All you need to do for this is collect just four or five dried urine samples over a 24-hour period.

 

With the DUTCH Plus, we take hormone testing to a whole new level. In addition to sex hormones and their metabolites, this panel looks at the overall diurnal pattern of free cortisol (think: STRESS), and the total and distribution of cortisol metabolites. Additionally, we analyze your Cortisol Awakening Response (CAR) which is left out of most Adrenal/Stress/HPA-Axis testing. The CAR is an important piece of information if you are stressed or wired and tired.

 

Even though a patient may have “normal” free cortisol levels throughout the day, that doesn’t always mean everything is functioning properly. The Cortisol Awakening Response is key to giving us a more well-rounded look at your unique stress response.

 

What does the DUTCH Plus test and report?

  • Metabolites of estrogens (10, including: E1, E2, E3, 2-OH-E1, 4-OH-E1, 2-OH-E2, 4-OH-E2, 16-OH-E1, 2-methoxy-E1, 2-methoxy-E2)

  • Androgens (8, including: Testosterone, DHT, and DHEA-S)

  • Progesterone (2)

  • Cortisol (3)

  • Melatonin (6OHMS)

  • 8-OHdG

  • Organic Acids (6)

  • Diurnal pattern of free cortisol AND cortisone

  • Cortisol Awakening Response.

 

We utilize DUTCH testing for effective monitoring of patients who are on Hormone Replacement Therapy. DUTCH testing was designed to be optimally effective for most forms of hormone replacement therapy. The lab uses unique methods for improved monitoring of oral progesterone and vaginal hormones.

 

DUTCH VS Saliva Testing

While the free cortisol pattern in saliva does have clinical value, there is a significant missing piece to surveying a patient’s HPA-Axis function with saliva testing. With saliva, we are unable to measure your cortisol metabolites. To properly analyze and characterize your stress response, free and metabolized cortisol are quite useful. Likewise, with sex hormones; measuring estrogen and androgen metabolites gives a much fuller picture for more precise clinical diagnosis of hormonal imbalances and HRT monitoring.

 

DUTCH VS Serum Testing

While the most universally accepted testing method, serum testing is lacking in some areas. Adrenal hormones cannot be effectively tested in serum (blood) because free cortisol cannot be tested throughout the day. Additionally, with serum hormone testing, there is a lack of extensive hormone metabolite testing (especially for cortisol and estrogens).